5-Sulfosalicylic acid dihydrate, for electrophoresis, ≥99% ยี่ห้อ Sigma

PROPERTIES

Quality Level

200

Assay

≥99%

form

powder or crystals

technique(s)

electrophoresis: suitable

impurities

≤0.02% Insoluble matter

≤0.05% Salicylic Acid

mp

105-110 °C (lit.)

solubility

water: soluble 100 mg/mL, clear, colorless

anion traces

chloride (Cl^-): ≤0.001%

sulfate (SO₄^2-): ≤0.035%

cation traces

Fe: ≤0.001%

heavy metals (as Pb): ≤0.002%

SMILES string

[H]O[H].[H]O[H].OC(=O)c1cc(ccc1O)S(O)(=O)=O

InChI

1S/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2

InChI key

BHDKTFQBRFWJKR-UHFFFAOYSA-N

DESCRIPTION

General description

5-Sulfosalicylic acid is a strong acid capable of protonating water.[1] It forms a new theophylline complex, which was investigated by X-ray photoelectron spectroscopy (XPS).[2] It forms 1:1 proton-transfer compounds with the ortho-substituted monocyclic heteroaromatic Lewis bases. Their crystal structures have been studied.[1]

Application

5-Sulfosalicylic acid (3.5%) in 12% trichloroacetic acid is commonly used as a fixing solution for proteins in agarose and polyacrylamide gels.

5-Sulfosalicylic acid dihydrate may be employed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma by HPLC.[3] It may be used in the preparation of poly[[tris(di-2-pyridylamine)tris([μ]-5-sulfonatosalicylato)tricopper(II)] trihydrate].[4]

Analysis Note

Tested for use in fixing solutions for PAGE, SDS-PAGE and IEF.