Palmitic acid BioXtra, ≥99% ยี่ห้อ Sigma
รหัสสินค้า : P5585
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PROPERTIES
biological source
plant (vegetable)
Quality Level
200
vapor pressure
10 mmHg ( 210 °C)
product line
BioXtra
Assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter
ign. residue
≤0.1%
bp
271.5 °C/100 mmHg (lit.)
mp
61-62.5 °C (lit.)
solubility
chloroform: 0.5 M, clear, colorless
density
0.852 g/mL at 25 °C (lit.)
anion traces
chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%
functional group
carboxylic acid
shipped in
ambient
storage temp.
room temp
SMILES string
CCCCCCCCCCCCCCCC(O)=O
InChI
1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
InChI key
IPCSVZSSVZVIGE-UHFFFAOYSA-N
Gene Information
human ... FABP2(2169) , FABP3(2170) , FABP4(2167) , FABP5(2171)
DESCRIPTION
Application
Palmitic acid has been used:
as a medium supplement in chorionic villous tissue culture form placenta[1]
as a component of hormone pellet for implantation in mice ovary[2]
for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1[3]
Biochem/physiol Actions
Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG).[4] Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer.[4][5] PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation.[6] PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation.[7] PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.[8]
Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.
SAFETY INFORMATION
Storage Class Code
11 - Combustible Solids
WGK
nwg
Flash Point(F)
235.4 °F
Flash Point(C)
113 °C
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