Pamidronate disodium salt hydrate ≥95% (NMR), solid ยี่ห้อ Sigma

PROPERTIES

Quality Level

100

Assay

≥95% (NMR)

form

solid

color

white

mp

300 °C

solubility

H2O: 28 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

InChI key

TVQNUQCYOOJTMK-UHFFFAOYSA-L

DESCRIPTION

Biochem/physiol Actions

Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs).[1] It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.[2]

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.