Orlistat ยี่ห้อ Sigma

PROPERTIES

biological source

synthetic (organic)

Quality Level

200

Assay

≥98%

form

solid

color

white

mp

<50 °C

solubility

DMSO: 19 mg/mL

originator

Roche

storage temp.

2-8°C

SMILES string

CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O

InChI

1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

InChI key

AHLBNYSZXLDEJQ-FWEHEUNISA-N

Gene Information

human ... LIPF(8513) , PNLIP(5406)

DESCRIPTION

Application

Orlistat has been used as an inhibitor:

of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines[1]

of lipase in screening lipase inhibition by raspberry extract[2]

in in vitro pancreatic lipase activity assay[3]

Biochem/physiol Actions

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity.[4] It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters.[5] Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.[6]

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Solution is not completely clear, small particles may remain floating.

SAFETY INFORMATION

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable