MILLIPLEX® Mouse High Sensitivity T Cell Panel- Premix Bulk (Space Saver) Packaging - Immunology Multiplex Assay ยี่ห้อ Sigma

DESCRIPTION

General description

Cytokines are immunomodulatory polypeptides that play key roles in both adaptive and innate immune responses. A generic term, “cytokines” includes myokines (produced by muscle cells), lymphokines (produced by activated Th cells), interleukins (acting as mediators between T cells), and chemokines (responsible for T-cell migration). One of the regulatory mechanisms of the immune system, cytokines act at the recognition, activation, or effector phases of an immune response, modulating the development and functional activities of the subtypes of T cells, B cells, and myeloid cells. Research involving cytokines plays a significant role in achieving a deeper understanding of the immune system and its multi-faceted response to most antigens, especially those responses that make up the inflammatory process.

Low levels of inflammation are involved in many clinical and sub-clinical disease states, such as autoimmune disease, cardiovascular disease, diabetes, neurological disorders, and cancer. Measuring picogram levels of cytokines, therefore, is critical for understanding the pathogenesis of these diseases.

The MILLIPLEX^® Mouse High Sensitivity T Cell Bead Panel is to be used for the simultaneous quantification of any or all of the following 18 mouse cytokines: GM-CSF, IFNγ, IL-1α, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12 (p70), IL-13, IL-17A, KC, LIX, MCP-1, MIP-2 and TNFα in mouse plasma, serum, and cell/tissue culture supernatant samples. This panel provides biomedical researchers quality tools for the study of low level inflammatory disease.

Panel Type: Cytokines/Chemokines

Application

·      Analytes: GM-CSF, IFNγ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12 (p70), IL-13, IL-17A, KC/CXCL1, LIX, MCP-1, MIP-2, TNF-α

·      Recommended Sample type: serum, plasma, tissue culture or other media

·      Recommended Sample dilution: neat or 1:2 diluted serum or plasma

·      Assay Run Time: Overnight

·      Research Category: Inflammation & Immunology

·      Research Subcategory: Immune Response Metabolic Disorders Chronic Inflammatory Disease Cardiovascular Disease

Other Notes

Please contact Technical Service for linearity of dilution.

Sensitivity: Please see protocol for sensitivity of individual analytes.

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany